Dr. David Sinclair's lab introduces a set of three genes into the optic nerve at the back of the eye and turns them on for 6 to 8 weeks to reset the age of cells.
AI Fact-Check
“Research from Dr. David Sinclair's lab at Harvard Medical School, published in the journal Nature in 2020, confirms this process. The method uses three of the four Yamanaka factors (Oct4, Sox2, and Klf4) delivered via a viral vector to retinal ganglion cells to reverse age-related vision loss in mice. The fourth factor, c-Myc, was excluded due to its association with cancer. Reports on this research and Sinclair's own descriptions confirm the genes are expressed for several weeks to achieve the age-reversal effect. Context: ⚠️ Actual number differs by >10%. This research was initially conducted in mice and has since been tested in non-human primates. A company co-founded by Sinclair, Life Biosciences, received FDA approval to begin human clinical trials for this gene therapy to treat certain forms of blindness, with trials expected to start in 2026.”
Source Videos (1)
Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests! - YouTube
The Diary Of A CEO and David Sinclair
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