In mice, infertility can be prevented and reversed.

“Multiple studies have demonstrated that age-related fertility decline in female mice can be reversed. A 2020 study published in Cell Reports, which included David Sinclair as a co-author, found that administering NMN (a precursor to NAD+) to older mice dramatically restored egg quality and increased live births. Another study published in Nature Aging in 2023 showed that the compound spermidine also improved oocyte quality and fertility in aged mice, resulting in larger litters. These findings support the claim that age-related infertility is reversible in mice. Context: The claim refers to age-related infertility in female mice. The research suggests that certain compounds can reverse the aging process in eggs, restoring their quality and viability. These findings have not yet been replicated in humans, but they offer a promising area of research for human fertility.”